Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia

Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia

Blog Article

Mutations of the SPAST gene that encodes the microtubule-severing enzyme called spastin are the chief cause of Hereditary Spastic Paraplegia.Growing evidence indicates that pathogenic mutations functionally compromise the spastin protein and endow it with Knives toxic gain-of-function properties.With each Uva Ursi of these two factors potentially relevant to disease etiology, the present article discusses possible therapeutic strategies that may ameliorate symptoms in patients suffering from SPAST-based Hereditary Spastic Paraplegia, which is usually termed SPG4-HSP.